H2N2V1, Main, Exploration, bibRecord, 002D81

[The evaluation of the degree of attenuation of cold-adapted influenza A virus strains in CBA-strain mouse and Syrian hamster models].

Identifieur interne : 002D81 ( Main/Exploration ); précédent : 002D80; suivant : 002D82

[The evaluation of the degree of attenuation of cold-adapted influenza A virus strains in CBA-strain mouse and Syrian hamster models].

Auteurs : G N Nevedomskaia ; T E Medvedeva ; I V Zhikhareva ; A I Klimov ; G I Aleksandrova

Source :

Voprosy virusologii [ 0507-4088 ]

RBID : pubmed:1413711

Descripteurs français

KwdFr :
- Adaptation physiologique, Animaux, Appareil respiratoire (microbiologie), Basse température, Cricetinae, Facteurs temps, Infections à Orthomyxoviridae (microbiologie), Infections à Orthomyxoviridae (étiologie), Mesocricetus (microbiologie), Modèles animaux de maladie humaine, Mâle, Souris, Souris de lignée CBA (microbiologie), Vaccins antigrippaux, Vaccins atténués, Virulence, Virus de la grippe A (isolement et purification), Virus de la grippe A (pathogénicité).
MESH :
- isolement et purification : Virus de la grippe A.
- microbiologie : Appareil respiratoire, Infections à Orthomyxoviridae, Mesocricetus, Souris de lignée CBA.
- pathogénicité : Virus de la grippe A.
- étiologie : Infections à Orthomyxoviridae.
- Adaptation physiologique, Animaux, Basse température, Cricetinae, Facteurs temps, Modèles animaux de maladie humaine, Mâle, Souris, Vaccins antigrippaux, Vaccins atténués, Virulence.

English descriptors

KwdEn :
- Adaptation, Physiological, Animals, Cold Temperature, Cricetinae, Disease Models, Animal, Influenza A virus (isolation & purification), Influenza A virus (pathogenicity), Influenza Vaccines, Male, Mesocricetus (microbiology), Mice, Mice, Inbred CBA (microbiology), Orthomyxoviridae Infections (etiology), Orthomyxoviridae Infections (microbiology), Respiratory System (microbiology), Time Factors, Vaccines, Attenuated, Virulence.
MESH :
- chemical : Influenza Vaccines, Vaccines, Attenuated.
- etiology : Orthomyxoviridae Infections.
- isolation & purification : Influenza A virus.
- microbiology : Mesocricetus, Mice, Inbred CBA, Orthomyxoviridae Infections, Respiratory System.
- pathogenicity : Influenza A virus.
- Adaptation, Physiological, Animals, Cold Temperature, Cricetinae, Disease Models, Animal, Male, Mice, Time Factors, Virulence.

Abstract

The pattern of the infectious process induced by the epidemic A/Leningrad/134/57 (H2N2) virus and its cold-adapted (CA) variants in CBA mice and Syrian hamsters was studied. The strains under study inoculated into the animals under a mild ether anesthesia differed by virulence, reproductive capacity in the nasopharynx, trachea and lungs, as well as by the isolation rate from extrarespiratory organs of both mice and hamsters. Upon intranasal inoculation of mice without anesthesia, the CA strains were found to be incapable of dissemination into the lower parts of the respiratory tract with distinguished these viruses from the original epidemic strain A/Leningrad/134/57 as well as from the mouse-adapted strain A/PR/8/34 (H1N1) used as control. The experimental results show that both models are suitable for laboratory evaluation of the attenuation degree of human influenza viruses.

PubMed: 1413711

Affiliations:

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">[The evaluation of the degree of attenuation of cold-adapted influenza A virus strains in CBA-strain mouse and Syrian hamster models].</title>
<author><name sortKey="Nevedomskaia, G N" sort="Nevedomskaia, G N" uniqKey="Nevedomskaia G" first="G N" last="Nevedomskaia">G N Nevedomskaia</name>
</author>
<author><name sortKey="Medvedeva, T E" sort="Medvedeva, T E" uniqKey="Medvedeva T" first="T E" last="Medvedeva">T E Medvedeva</name>
</author>
<author><name sortKey="Zhikhareva, I V" sort="Zhikhareva, I V" uniqKey="Zhikhareva I" first="I V" last="Zhikhareva">I V Zhikhareva</name>
</author>
<author><name sortKey="Klimov, A I" sort="Klimov, A I" uniqKey="Klimov A" first="A I" last="Klimov">A I Klimov</name>
</author>
<author><name sortKey="Aleksandrova, G I" sort="Aleksandrova, G I" uniqKey="Aleksandrova G" first="G I" last="Aleksandrova">G I Aleksandrova</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="????"><PubDate><MedlineDate>1992 Jan-Feb</MedlineDate>
</PubDate>
</date>
<idno type="RBID">pubmed:1413711</idno>
<idno type="pmid">1413711</idno>
<idno type="wicri:Area/PubMed/Corpus">000438</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000438</idno>
<idno type="wicri:Area/PubMed/Curation">000438</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000438</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000622</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000622</idno>
<idno type="wicri:Area/Ncbi/Merge">000083</idno>
<idno type="wicri:Area/Ncbi/Curation">000083</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000083</idno>
<idno type="wicri:doubleKey">0507-4088::Nevedomskaia G:the:evaluation:of</idno>
<idno type="wicri:Area/Main/Merge">002F56</idno>
<idno type="wicri:Area/Main/Curation">002D81</idno>
<idno type="wicri:Area/Main/Exploration">002D81</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">[The evaluation of the degree of attenuation of cold-adapted influenza A virus strains in CBA-strain mouse and Syrian hamster models].</title>
<author><name sortKey="Nevedomskaia, G N" sort="Nevedomskaia, G N" uniqKey="Nevedomskaia G" first="G N" last="Nevedomskaia">G N Nevedomskaia</name>
</author>
<author><name sortKey="Medvedeva, T E" sort="Medvedeva, T E" uniqKey="Medvedeva T" first="T E" last="Medvedeva">T E Medvedeva</name>
</author>
<author><name sortKey="Zhikhareva, I V" sort="Zhikhareva, I V" uniqKey="Zhikhareva I" first="I V" last="Zhikhareva">I V Zhikhareva</name>
</author>
<author><name sortKey="Klimov, A I" sort="Klimov, A I" uniqKey="Klimov A" first="A I" last="Klimov">A I Klimov</name>
</author>
<author><name sortKey="Aleksandrova, G I" sort="Aleksandrova, G I" uniqKey="Aleksandrova G" first="G I" last="Aleksandrova">G I Aleksandrova</name>
</author>
</analytic>
<series><title level="j">Voprosy virusologii</title>
<idno type="ISSN">0507-4088</idno>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adaptation, Physiological</term>
<term>Animals</term>
<term>Cold Temperature</term>
<term>Cricetinae</term>
<term>Disease Models, Animal</term>
<term>Influenza A virus (isolation & purification)</term>
<term>Influenza A virus (pathogenicity)</term>
<term>Influenza Vaccines</term>
<term>Male</term>
<term>Mesocricetus (microbiology)</term>
<term>Mice</term>
<term>Mice, Inbred CBA (microbiology)</term>
<term>Orthomyxoviridae Infections (etiology)</term>
<term>Orthomyxoviridae Infections (microbiology)</term>
<term>Respiratory System (microbiology)</term>
<term>Time Factors</term>
<term>Vaccines, Attenuated</term>
<term>Virulence</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adaptation physiologique</term>
<term>Animaux</term>
<term>Appareil respiratoire (microbiologie)</term>
<term>Basse température</term>
<term>Cricetinae</term>
<term>Facteurs temps</term>
<term>Infections à Orthomyxoviridae (microbiologie)</term>
<term>Infections à Orthomyxoviridae (étiologie)</term>
<term>Mesocricetus (microbiologie)</term>
<term>Modèles animaux de maladie humaine</term>
<term>Mâle</term>
<term>Souris</term>
<term>Souris de lignée CBA (microbiologie)</term>
<term>Vaccins antigrippaux</term>
<term>Vaccins atténués</term>
<term>Virulence</term>
<term>Virus de la grippe A (isolement et purification)</term>
<term>Virus de la grippe A (pathogénicité)</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Influenza Vaccines</term>
<term>Vaccines, Attenuated</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Orthomyxoviridae Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Influenza A virus</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Appareil respiratoire</term>
<term>Infections à Orthomyxoviridae</term>
<term>Mesocricetus</term>
<term>Souris de lignée CBA</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Mesocricetus</term>
<term>Mice, Inbred CBA</term>
<term>Orthomyxoviridae Infections</term>
<term>Respiratory System</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Influenza A virus</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Infections à Orthomyxoviridae</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adaptation, Physiological</term>
<term>Animals</term>
<term>Cold Temperature</term>
<term>Cricetinae</term>
<term>Disease Models, Animal</term>
<term>Male</term>
<term>Mice</term>
<term>Time Factors</term>
<term>Virulence</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adaptation physiologique</term>
<term>Animaux</term>
<term>Basse température</term>
<term>Cricetinae</term>
<term>Facteurs temps</term>
<term>Modèles animaux de maladie humaine</term>
<term>Mâle</term>
<term>Souris</term>
<term>Vaccins antigrippaux</term>
<term>Vaccins atténués</term>
<term>Virulence</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The pattern of the infectious process induced by the epidemic A/Leningrad/134/57 (H2N2) virus and its cold-adapted (CA) variants in CBA mice and Syrian hamsters was studied. The strains under study inoculated into the animals under a mild ether anesthesia differed by virulence, reproductive capacity in the nasopharynx, trachea and lungs, as well as by the isolation rate from extrarespiratory organs of both mice and hamsters. Upon intranasal inoculation of mice without anesthesia, the CA strains were found to be incapable of dissemination into the lower parts of the respiratory tract with distinguished these viruses from the original epidemic strain A/Leningrad/134/57 as well as from the mouse-adapted strain A/PR/8/34 (H1N1) used as control. The experimental results show that both models are suitable for laboratory evaluation of the attenuation degree of human influenza viruses.</div>
</front>
</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Aleksandrova, G I" sort="Aleksandrova, G I" uniqKey="Aleksandrova G" first="G I" last="Aleksandrova">G I Aleksandrova</name>
<name sortKey="Klimov, A I" sort="Klimov, A I" uniqKey="Klimov A" first="A I" last="Klimov">A I Klimov</name>
<name sortKey="Medvedeva, T E" sort="Medvedeva, T E" uniqKey="Medvedeva T" first="T E" last="Medvedeva">T E Medvedeva</name>
<name sortKey="Nevedomskaia, G N" sort="Nevedomskaia, G N" uniqKey="Nevedomskaia G" first="G N" last="Nevedomskaia">G N Nevedomskaia</name>
<name sortKey="Zhikhareva, I V" sort="Zhikhareva, I V" uniqKey="Zhikhareva I" first="I V" last="Zhikhareva">I V Zhikhareva</name>
</noCountry>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002D81 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002D81 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    H2N2V1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:1413711
   |texte=   [The evaluation of the degree of attenuation of cold-adapted influenza A virus strains in CBA-strain mouse and Syrian hamster models].
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:1413711" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a H2N2V1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 14 19:59:40 2020. Site generation: Thu Mar 25 15:38:26 2021

Serveur d'exploration H2N2

[The evaluation of the degree of attenuation of cold-adapted influenza A virus strains in CBA-strain mouse and Syrian hamster models].

[The evaluation of the degree of attenuation of cold-adapted influenza A virus strains in CBA-strain mouse and Syrian hamster models].

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration H2N2
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.